ఫార్మాస్యూటికా అనలిటికా ఆక్టా

నైరూప్య

Understanding the Mechanism of Antioxidant Potential of Organochalcogens in Rat's Brain Preparation

Waseem Hassan, Senthil Narayanaperumal, Matheus M. Santos, Kashif Gul, Imdad Ullah Mohammadzai, Antonio L. Braga, Oscar Dorneles Rodrigues and Joao B. T. Rocha

In the quest to explore mechanism of action of organochalcogens a series of them are tested for their structuralactivity relationship using rat’s brain preparation. Dichalcogenides are better anti-oxidants than structurally analogues mono- chalcogenides. Effects of electron donating and withdrawing groups have been explored and explained in detail. We have also proved that structural isomerisation does not influence the anti-oxidant activity of these compounds.