గ్లోబల్ జర్నల్ ఆఫ్ బయాలజీ, అగ్రికల్చర్ & హెల్త్ సైన్సెస్

నైరూప్య

Toxicological Evaluation of Syrup from Rhizophora mucronata Hypocotyls Ethanolic Extract in Sprague–Dawley Rats

Indah Rahayu Widadi, Sri Purwaningsih, & Ietje Wientarsih

Rhizophora mucronata hypocotyls extract is known to be a new antioxidant and hepatoprotector supplement syrup. Thus, its toxicological profile needs to be studied. At present, the syrup from R. mucronata hypocotyls ethanolic extract was evaluated for the 28 day repeated dose (subacute) toxicological evaluation. The Sprague dawley rats were treated with with three dose (15, 105, and 735 mg/kg bw) syrup and administered orally for a period of 28 days in rats. The effects on body weight and clinical biochemistry were studied. There were no significant differences in the body weight between control and treated animals. There were no significant changes that occurred in the blood chemistry analysis including total bilirubin, blood urea nirogen, creatinine, SGPT, and SGOT in experimental animals. The syrup from R. mucronata hypocotyls ethanolic extract was found safe in 28 day repeated dose toxicity studies