David Arthon
As a customary Chinese medication, lotus leaf was accounted
for to have critical hepatoprotective impact. To investigate the
hepatoprotective system of lotus leaf, a quick and solid UPLC-MS/
MS strategy was led to all the while decide six explicit endogenous
substances including 5-oxoproline, phenylalanine, tryptophan,
C18-phytosphingosine, lysophosphatidylcholine (16 : 0) and
lysophosphatidylcholine (18 : 1). With the assistance of HPLC–
FT-ICR-MS, the synthetic constituents of brutes leaf remove were
clarified. By watching histopathological changes and deciding
hepatotoxicity-related biochemical markers, rodent model of
liver injury was created and the hepatoprotective impact of lotus
leaf was confirmed.