జర్నల్ ఆఫ్ బ్లడ్ డిజార్డర్స్ & ట్రాన్స్‌ఫ్యూజన్

నైరూప్య

Prevalence of Hyperuricemia and the Relationship Serum Uric Acid with a Musculoskeletal Complication in Patients with β Thalassemia Intermedia

Peyman Etemadfar*, S. Anbari

Background: Beta thalassemia (β-thalassemia), which is one of the most common monogenic diseases in the world, is caused by a decrease or lack of synthesis of the beta-globin chain. Patients with thalassemia major are associated with ineffective erythropoiesis, chronic hemolysis of erythrocytes, and increased production of uric acid. Complications such as musculoskeletal complications, osteoporosis have been reported in these patients. Studies in general populations have also shown that elevated serum uric acid levels are associated with increased bone mineral density.

Patients and methods: This cross-sectional descriptive and analytical study was performed on 48 patients in Yasuj City (Southwest Iran). We collect the information in the patients’ file and analyzed blood samples of patients Thalassemia Intermedia referring to Yasuj city. The tests were performed by the reference laboratory of the Blood Transfusion Organization of Iran. Statistical significance was based on two-sided design-based tests evaluated at the 0.05 level of significance. All the statistical analyses were performed by SPSS 20 software.

Results: The mean age of the patients was 46.15 ± 13.05 years. The uric acid level had a significant relationship with the Lumbar Z score in men patients (p-value=0.02). The mean Lumbar Z score in people with uric acid levels less than 6.1 was in the osteoporotic range and people with uric acid levels more were equal to 6.2 in the osteopenia range. Most people with thalassemia intermedia had osteopenia, but no significant relationship was found between blood uric acid levels in women and bone mineral density.

Conclusion: Most people with thalassemia intermedia had osteopenia, but no significant relationship was found between blood uric acid levels in women and bone mineral density.