బాక్టీరియాలజీ & పారాసిటాలజీ జర్నల్

నైరూప్య

Multidrug resistant and Extensively drug resistant TB: A Nuisance to Medical Science

Rohit Singh, Rajni, Anita Meena and Laxman S. Meena

Tuberculosis is the topic of discussion for researchers due to the indocile nature of its causative micro-organism, Mycobacterium tuberculosis H37Rv (MTB). MTB escapes the human immune system by employing different strategies to render the drugs used for treatment ineffective, due to ultimate alterations in genes such as gyr 90, 91 and 94 which make it resistant to different drugs. Different techniques and methodologies are being developed and used to diagnose, treat and prevent the spread of the disease caused due to drug-resistant MTB. Drug resistance is reported from all over the world. Although very less treatment options are available in case of MDR and XDR-TB but still they are curable. HIV co-infection is also a big hurdle in the way of successful treatment of drug resistant TB as drug-drug interaction is an issue. It is better to improve the community medicine system to battle the TB in a better way. Highest percent of people is showing the resistant against INH so one should be careful about this fact while using the INH in regimen.