జర్నల్ ఆఫ్ క్లినికల్ & ఎక్స్‌పెరిమెంటల్ ఫార్మకాలజీ

నైరూప్య

Leaves Extract of Muntingia Calabura Protects Against Gastric Ulcer Induced by Ethanol in Sprague-Dawley Rats

Ibrahim Abdel Aziz Ibrahim ,Mahmood Ameen Abdulla ,Siddig Ibrahim Abdelwahab *,Fouad Al-Bayaty ,Nazia Abdul Majid

Aim: Muntingia calabura is a medicinal plant used popularly known in Malaysia against various diseases including peptic ulcer. This study was performed to evaluate the gastroprotective effect of ethanolic extracts of Muntingia calabura Leaf Extract (MCELE) against ethanol-induced gastric mucosal injury in experimental rats.
Methods: The rats were divided into four groups respectively pre-treated orally with Carboxymethyl Cellulose (CMC) solution (ulcer control groups), omeprazole 20 mg/kg (reference group), 250 and 500 mg/kg of MCELE (experimental groups) one hour before oral administration of absolute ethanol to generate gastric mucosal damage. After an additional hour, the rats were sacrificed and the ulcerated areas of the gastric walls were determined.
Results: The ulcer control group exhibited severe mucosal injury, whereas groups pre-treated with the MCELE exhibited significant protection of gastric mucosa. These findings were also confirmed by histology of the gastric wall. Significant increases in gastric mucus production and decrease in acidity of gastric content were observed in the treated groups with MCELE compare to ulcer control group.
Conclusions: The treatment with MCLELE prior to absolute alcohol has significantly protect gastric mucosa as ascertained by significant reduction of ulcer area, increases in gastric mucus production, decrease the acidity of gastric content and histology by comparatively decreases gastric mucosal injury, reduction of oedema and leukocyte infiltration of submucosal layer. MCELE was able to decrease the acidity and increase the mucosal defence in the gastric area, thereby justifying its use as an antiulcerogenic agent