ఆధునిక కెమిస్ట్రీ & అప్లికేషన్స్

నైరూప్య

Isolation, Characterization and Analgesic Activity of Natural Allantoin from Portulaca oleracea Seed

Heng-Zhi Wang, Chuan-Jin Wang

The title compound, allantoin was first isolated from the acetyl acetate fraction of Portulaca oleracea seed and characterized by ¹H-NMR and ¹³C-NMR. The analgesic activity of allantoin was assessed in acetic acid-induced writhing test in mice with i.p. injection. The results of the research indicated that the analgesic activity of allantoin was similiar to that of aspirine. After administrated of allantoin regularly and repeatedly, the mice did not reveal addiction phenomenon. Allantoin could be further studied as a promising analgesic drug.