Balaji Krishnaiah, Vitaliy Zhivotenko, Mayur Chalia, Charles Specht and Aiesha Ahmed
Introduction: Intraneural perineurioma is a rare benign tumor composed of perineural cells. It typically affects teenagers and young adults and tends to present as a gradual onset motor predominant neuropathy. Pain and sensory disturbances are uncommon.
Methods: We discuss a case of sciatic perineurioma which was diagnosed with the help of multiple diagnostic modalities including electro diagnostic testing, imaging and biopsy.
Results: An electro diagnostic study was done which showed chronic severe left sciatic neuropathy with on-going denervation and MRI of the left lower extremity revealed enlargement and increase signal of the left sciatic nerve. A left sciatic nerve biopsy revealed intraneural perineurioma.
Conclusion: Intraneural perineurioma should be included in the differential diagnosis of focal neuropathy in a young adult. Imaging and electro diagnostic studies can be useful to indicate the likely presence of an intraneural neoplasm.