జర్నల్ ఆఫ్ అలెర్జీ & థెరపీ

నైరూప్య

Group-specific Multi-allergen Sublingual/Swallow Immunotherapy Improves the Quality of Life of Polysensitized Children and Adults with Allergic Rhinitis

Celso Eduardo Olivier, Regiane Patussi dos Santos Lima, Daiana Guedes Pinto Argentão, Mariana Dias da Silva, Raquel Acácia Pereira Gonçalves dos Santos, Marcus Pensuti and Thaís Helena Piai-de-Morais

Background: The treatment of polysensitized allergic patients continues to represent a challenge and is a matter for debate amongst allergists who preferentially use allergen-specific immunotherapy.

Objective: To study the effect of group-specific sublingual/swallow immunotherapy on quality of life of polysensitized human subjects with allergic rhinitis diagnosed using a comprehensive panel of cutaneous tests.

Methods: 60 polysensitized subjects diagnosed with allergic rhinitis who submitted to group-specific sublingual/ swallow immunotherapy treatment corresponding to their cutaneous sensitizations, and who completed 6 months of treatment without the use of any complementary medication were evaluated with a validated quality of life questionnaire.

Results: There were significant improvements in all quality of life categories evaluated, which included: sleep, systemic symptoms, practical problems, nasal symptoms, eye symptoms, activities and emotions.

Conclusions: The administration of a group-specific multi-allergen sublingual/swallow immunotherapy as indicated by a comprehensive panel of sensitizing agents in cutaneous tests performed by a specialized team, significantly improved the quality of life of human polysensitized subjects with allergic rhinitis without the use of any additional medication.