నానోమెడిసిన్ & నానోటెక్నాలజీ జర్నల్

నైరూప్య

Effect of Coffee Daily Consumption Uric Acid Level and Body Weight to Prevent Metabolic Syndrome

Rosa Lelyana

Obesity was one of diagnosis criteria of metabolic syndrome. There was increasing mortality case of obesity in recent decade. High uric acid level was the early marker of metabolic syndrome. Coffee was one of favorite drink of obese and non obese people in the world. Thus we investigated the effects of coffee drinking for preventing metabolic syndrome. This study was conducted by true experimental with randomized controlled group pretest-posttest design. Twenty four male wistar rats (10 weeks) were fed a standar density diet with and without 0.72 ml coffee solution dailyduring 14 days. Treatment and control group were greatest difference in the last day (day-14) or after study (t=- 2.24; p<0.05). The difference in body weight decrease was bigger in treatment group. The difference in body weight increase became bigger with longer time in control group. Mean of body weight difference during 14 days, differed significantly (t=-4.59; p=0.00) between treatment (n=12) and control group (n=12). Mean of obese uric acid level at the start of study was higher than obese uric acid level at the end of study although the difference was not significant (p>0.05). Drinking 0.72 ml (equal with 2 cup of coffee in human) coffee daily during 14 days decreased uric acid level in obese rats model although not significant. Coffee has activity as antiobesity and has preventieve action against metabolic syndrome disease.