ఆధునిక కెమిస్ట్రీ & అప్లికేషన్స్

నైరూప్య

Trends in Characterization of PEGylated Proteins by Mass Spectrometry

Daniela Hutanu and Costel C Darie

Characterization of PEGylated proteins in crucial in the biotechnology industry for quality control and formulation purposes. This mini review lists several Mass Spectrometry (MS) methods employed in the past 20 years for PEGylated protein analysis. The trend seems to shift from predominantly qualitative MALDI, to liquid chromatography coupled with MS for quantitative or conformational studies.