బయోకెమిస్ట్రీ & అనలిటికల్ బయోకెమిస్ట్రీ

నైరూప్య

Multiple Myeloma with Biclonal Gammopathy of IgA Kappa Variant: A Case Report

Anurag Yadav, Ramlinga Reddy and Malathi M

Introduction: Multiple myeloma is a plasma cell cancer causing infiltration of bone marrow and presence of monoclonal proteins in plasma and/or the Urine causing mortality and morbidity. Multiple myeloma with Biclonal Gammopathy is rare and accounting about 1-2%.
Clinical case description: In this report, we encountered a patient presented with backache and weakness since a month, the lab investigation revealed reversal A/G ratio suspected towards para-protein and electrophoresis showed 2 distinct band in the gamma region, peripheral smear, bone marrow and X-ray reports supported findings, urine positive for Bence Jones Protein, Immunofixation showed 2 distinct bands in IgA and Kappa region. It is a rare Immunofixation pattern which is seen in any multiple myeloma cases.
Conclusion: Hence with the clinical feature and the investigation the multiple myeloma was found to be positive, and 2 bands in IgA and kappa region pointing it to be a Biclonal Gammopathy.