నానోమెడిసిన్ & నానోటెక్నాలజీ జర్నల్

నైరూప్య

In Vitro Anticancer Activity of Biogenic Tio2 nps against Breast Cancer, Lungs Cancer and Prostate Cancer

Shama Parveen1, Dr. VikasGupta1*, Sudipa Devi2

In this research, we report a novel plant-mediated method as for manufacture of titanium dioxide nanoparticles. Utilizing the titanium oxide derivative and a plant extract from the native medicinal herb Leucas cephalotes, the nanoparticles were effectively created. The reaction temperature was kept between 75°C and 80°C while 1M of TiO2 and the plant extract were being processed. The resulting white colored paste was completely parched, gathered, and packaged to more investigation. The absorption peak for titanium dioxide nanoparticles in the UV-Vis spectrometer was seen at 212 and 345 nm. The typical dimension of the nanoparticles was determined to be 38.99 nm from the XRD pattern. According to the findings, titanium and oxygen are composed with high energy signals of 61.27% and 23.16%, respectively. The Ti-O bonding absorption peak, as determined by FT-IR spectroscopic investigation, is situated at 586 cm1. SEM (scanning electron microscopy) was employed to confirm the spherical shape of the synthesized TiO2NPs. The creation of nanoTiO2-NPs is confirmed by the several characterization techniques used. The green synthesis-produced titanium dioxide nanoparticles could be used to treat a variety of malignancies. MTS and MTT assays were used to assess the anticancer activity of the biogenic titanium dioxide oxide nanoparticles. The IC50 values of the produced were 1.89, 2.00, 1.98, and 4.00 μM, respectively, against the MCF-7, HeLa, PC-3, and A549 nanoparticles cancer cell lines.

Keywords

Biogenic synthesis TiO₂, Characterization, Anticancer activity