జర్నల్ ఆఫ్ బయోక్వివలెన్స్ & బయోఎవైలబిలిటీ

నైరూప్య

Comparative Pharmacokinetic Profile of Aceclofenac from Oral and Transdermal Application

Faiyaz Shakeel, Mohammed S Faisal and Sheikh Shafiq

The aim of the present investigation was to compare pharmacokinetic profile (bioavailability) of aceclofenac by transdermal and oral application. Nanoemulsion, nanoemulsion gel and marketed tablet (Aceclofar ® ) were subjected to pharmacokinetic (bioavailability) studies on Wistar male rats. Several pharmacokinetic parameters like C max , t max , AUC 0 → t , AUC 0 → α , K e , and T 1/2 were determined for each formulation. The absorption of aceclofenac by transdermally applied nanoemulsion and nanoemulsion gel resulted in 2.95 and 2.60 fold increase in bioavailability as compared to oral tablet formulation. Results of these studies indicated that the nanoemulsions can be successfully used as potential vehicle for enhancement of bioavailability of aceclofenac.